Digital Twin

The AI hype in pharma has mostly yielded faster failures. Despite generative models for molecules and AlphaFold for protein folding, the fundamental chasm remains: what works in silico or in vitro still too often flops in vivo. A new proposal — Programmable Virtual Humans (PVHs) — may finally aim high enough: modeling the entire cascade of drug action across human biology, not just optimizing isolated steps. 🧬 The Translational Gap Isn’t Just a Data Problem Most AI models in drug discovery focus on digitizing existing methods. Target-based models optimize binding affinity; phenotype-based approaches predict morphology changes in cell lines. But both ignore the reality that molecular behavior in humans is emergent — shaped by multiscale interactions between genes, proteins, tissues, and organs. ...

In the age of Digital Twins and hyper-automated warehouses, simulations are everywhere—but insights are not. Discrete Event Simulations (DES) generate rich, micro-level data on logistics flows, delays, and resource utilization, yet interpreting these data remains painfully manual, fragile, and siloed. This paper from Quantiphi introduces a compelling solution: transforming raw simulation outputs into a Knowledge Graph (KG) and querying it via an LLM agent that mimics human investigative reasoning. It’s a shift from spreadsheet-style summaries to an interactive AI assistant that explains why something is slow, where the bottleneck is, and what needs attention. ...

Twin It to Win It: How BedreFlyt Reimagines Hospital Resource Planning Hospitals often operate under intense pressure, juggling patient needs, staff availability, and limited resources. Now imagine an AI-powered assistant that anticipates those needs, simulates complex patient flows, and delivers optimized resource plans—without burning out the staff. That’s the promise of BedreFlyt, a modular, simulation-driven Digital Twin (DT) designed for hospital wards. Developed at the University of Oslo, BedreFlyt isn’t just another simulation tool. It uniquely integrates: ...