Aligning the Unalignable: How CORE Redefines Multistain Image Registration
Opening — Why this matters now Modern pathology is going digital at breakneck speed, yet the transition hides a deceptively analog bottleneck: aligning images that never quite match. Tissue slides stained with hematoxylin-eosin, immunofluorescence, or PAS may originate from the same biopsy—but their digital twins rarely align pixel-to-pixel. This mismatch thwarts the holy grail of computational pathology: integrating structure, function, and molecular signals into one coherent visual map. ...