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Aligning the Unalignable: How CORE Redefines Multistain Image Registration

Slides do not politely stay aligned. A pathology lab may scan an H&E slide for tissue architecture, an IHC slide for protein expression, a PAS slide for renal structure, and a multiplex immunofluorescence slide for cellular markers. The human story is that these images come from the same biopsy. The computational story is less sentimental: the tissue has been sliced, stained, bleached, re-stained, stretched, torn, folded, scanned, and generally treated like a fragile biological object in a world built for rectangles. ...

November 9, 2025 · 14 min · Zelina