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Doctor, Interrupted: How Multi-Agent AI Revives the Lost Art of Pre‑Consultation

TL;DR for operators This paper is best read as a workflow paper, not a miracle-doctor paper. It shows that pre-consultation AI becomes more useful when it stops behaving like a polite symptom box and starts behaving like an intake coordinator with a checklist, memory, and a sense of unfinished business. The system decomposes pre-consultation into triage, history of present illness, past history, and chief complaint generation. A Controller agent decides what still needs to be asked. A Monitor agent checks whether subtasks are complete. A Prompter and Inquirer convert those gaps into the next clinical question. This is less theatrical than “AI doctor,” which is precisely why it matters. ...

November 6, 2025 · 13 min · Zelina
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From Molecule to Mock Human: Why Programmable Virtual Humans Could Rewrite Drug Discovery

TL;DR for operators A recent paper proposes programmable virtual humans (PVHs): dynamic, multiscale computational models intended to simulate how a new molecule moves through, interacts with, and perturbs human biology from molecular binding to clinical phenotype.1 The operational point is not that pharma now has a magic patient simulator. It does not. The paper is a perspective and roadmap, not a benchmarked product release with clinical validation, regulatory acceptance, and a procurement form attached. Shame, really. ...

July 29, 2025 · 18 min · Zelina