The Extra Molecular Signal Has a Different Job
TL;DR for operators Adding another molecular signal to a diagnostic AI system does not necessarily improve its classification accuracy. MOXAI demonstrates that combining DNA methylation and copy number information can reduce variability across validation folds even when methylation alone remains more accurate. The study also separates two qualities often treated as interchangeable: predictive performance and explanation quality. DINOv2 achieves 81.30% accuracy on an independent glioblastoma cohort, compared with 67.48% for ResNet50, but ResNet50 produces more localized genomic attribution maps. DINOv2’s reported 94.25% accuracy applies only to predictions exceeding a 0.9 confidence threshold. ...